Chuanzhu Yan Selected Research

Atherosclerosis

4/2024	Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function.
9/2023	Combining idebenone and rosuvastatin prevents atherosclerosis by suppressing oxidative stress and NLRP3 inflammasome activation.
12/2021	Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway.
5/2016	Reduced Serum Level of Interleukin-10 is Associated with Cerebral Infarction: A Case-Control and Meta-Analysis Study.
9/2015	Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways.

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Chuanzhu Yan Research Topics

Disease

17	Mitochondrial Diseases (Mitochondrial Disease) 03/2024 - 03/2014
9	Muscular Diseases (Myopathy) 09/2023 - 10/2012
7	MELAS Syndrome (Syndrome, MELAS) 01/2023 - 06/2002
6	Muscle Weakness 01/2023 - 02/2010
5	Atherosclerosis 04/2024 - 09/2015
5	Stroke (Strokes) 01/2022 - 03/2014
5	Dermatomyositis (Dermatopolymyositis) 01/2022 - 08/2015
4	Atrophy 06/2022 - 01/2016
4	Myositis (Idiopathic Inflammatory Myopathies) 01/2022 - 06/2015
4	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2021 - 07/2015
3	Myopathy with Abnormal Lipid Metabolism 02/2024 - 02/2010
3	Glycogen Storage Disease Type II (Pompe's Disease) 01/2024 - 01/2016
3	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 01/2022
3	Myasthenia Gravis 01/2023 - 09/2017
3	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 01/2023 - 02/2010
3	Ataxia (Dyssynergia) 11/2022 - 04/2018
3	Inflammation (Inflammations) 01/2022 - 01/2011
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2016
3	Mitochondrial encephalopathy 01/2022 - 03/2014
3	Polymyositis 01/2022 - 06/2015
3	Lactic Acidosis 01/2022 - 03/2014
3	MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers) 11/2020 - 06/2002
3	Brain Diseases (Brain Disorder) 01/2020 - 02/2010
2	Rare Diseases (Rare Disease) 05/2024 - 10/2022
2	Nervous System Diseases (Neurological Disorders) 10/2023 - 01/2016
2	Atherosclerotic Plaque (Atheroma) 09/2023 - 12/2021
2	Nemaline Myopathies (Nemaline Myopathy) 02/2023 - 01/2022
2	Disease Progression 01/2023 - 11/2020
2	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 01/2023 - 01/2022
2	Muscular Dystrophies (Muscular Dystrophy) 01/2023 - 01/2021
2	Tremor (Tremors) 01/2023 - 01/2022
2	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2023 - 01/2021
2	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 01/2022 - 06/2002
2	Type 2G Limb-Girdle Muscular Dystrophy 01/2022 - 01/2021
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 11/2020
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 07/2016
2	Dysferlinopathy 12/2021 - 06/2016
2	Myoclonus (Nocturnal Myoclonus) 11/2020 - 03/2014
2	Cerebellar Ataxia (Dysmetria) 11/2020 - 03/2014
2	Neutral Lipid Storage Disease with Myopathy 10/2019 - 10/2012
2	Vomiting 06/2015 - 03/2014
2	Parkinson Disease (Parkinson's Disease) 01/2015 - 01/2011
2	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 03/2014 - 06/2002
1	Visceral myopathy familial external ophthalmoplegia 05/2024
1	Myotoxicity 04/2024
1	Lipid Metabolism Disorders (Metabolism Disorders, Lipid) 01/2024
1	Glycogen Storage Disease (Glycogenosis) 01/2024
1	Edema (Dropsy) 01/2024

Drug/Important Bio-Agent (IBA)

6	Mitochondrial DNA (mtDNA)IBA 05/2024 - 03/2016
6	Riboflavin (Vitamin B2)FDA LinkGeneric 02/2024 - 02/2010
5	idebenoneIBA 04/2024 - 09/2015
4	AcidsIBA 01/2024 - 02/2010
4	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2013
4	AntibodiesIBA 01/2022 - 01/2019
4	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 03/2014
4	LipidsIBA 11/2018 - 02/2010
3	Apolipoproteins E (ApoE)IBA 04/2024 - 12/2021
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2024 - 01/2022
3	coenzyme Q10 (CoQ10)IBA 03/2024 - 01/2021
3	Creatine Kinase (Creatine Phosphokinase)IBA 01/2024 - 12/2017
3	oxidized low density lipoproteinIBA 09/2023 - 09/2015
3	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2017
3	Rituximab (Mabthera)FDA Link 01/2023 - 01/2022
3	Oxidoreductases (Dehydrogenase)IBA 01/2023 - 06/2013
3	Therapeutic UsesIBA 01/2022 - 03/2014
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 03/2014
3	Transfer RNA (tRNA)IBA 01/2022 - 01/2020
3	fibroblast growth factor 21IBA 01/2020 - 07/2015
2	Triglycerides (Triacylglycerol)IBA 01/2024 - 02/2010
2	alpha-Glucosidases (Acid Maltase)IBA 01/2024 - 01/2016
2	Phosphotransferases (Kinase)IBA 10/2023 - 01/2023
2	NucleotidesIBA 09/2023 - 10/2022
2	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2023 - 01/2021
2	Bile Acids and Salts (Bile Acids)IBA 01/2023 - 11/2020
2	Electron-Transferring Flavoproteins (Electron Transfer Flavoprotein)IBA 01/2023 - 06/2013
2	Immunoglobulin G (IgG)IBA 01/2023 - 01/2022
2	ConnectinIBA 01/2023 - 05/2022
2	2,2,2',4'-tetrachloroacetophenoneIBA 01/2023 - 01/2021
2	Lys Transfer RNAIBA 11/2022 - 11/2020
2	Staphylococcal Protein A (Protein A)IBA 01/2022 - 05/2021
2	SteroidsIBA 01/2022 - 01/2022
2	Ligases (Synthetase)IBA 01/2022 - 03/2007
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2022 - 01/2022
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2021 - 03/2014
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2021 - 11/2018
2	Growth Differentiation Factor 15IBA 01/2020 - 12/2017
2	Messenger RNA (mRNA)IBA 01/2017 - 07/2015
2	CateninsIBA 07/2016 - 09/2015
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2015 - 06/2015
2	Uridine Diphosphate (UDP)IBA 01/2013 - 04/2011
2	N-acylmannosamine kinaseIBA 01/2013 - 04/2011
2	Racemases and Epimerases (Epimerases and Racemases)IBA 01/2013 - 04/2011
2	AcetylglucosamineIBA 01/2013 - 04/2011
1	Thymidine PhosphorylaseIBA 05/2024
1	NucleosidesIBA 05/2024
1	Amylases FDA Link 01/2024
1	GlycogenIBA 01/2024
1	glycogeninIBA 01/2024

Therapy/Procedure

10	Therapeutics 09/2023 - 01/2015
2	Denervation 01/2019 - 01/2016